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This process is most pronounced in metabolically stressed cells, and the accelerated damage to these organelles can lead to premature dysfunction and early cell senescence, culminating in cell death [24]

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Tamm-Horsfall protein (THP), alternatively known as uromodulin (UMOD), is a phosphatidylinositol-anchored glycoprotein exclusively formed by renal tubular cells (TAL) situated in the rising rough segment of the Henle loop (124)